The publishing house of Charles Scribner's Sons first commissioned Wyeth to illustrate Robert Louis Stevenson's Treasure Island in 1911. The 17 paintings that make up Treasure Island’s illustration set are celebrated in American book illustration, combining realistic action and a heightened contrast between light and shadow to enrich the story well beyond the text.
These pictures made the Wyeth-illustrated edition of Treasure Island a favorite of generations of readers. So well received was his first book, that Wyeth illustrated a whole range of "boy's adventure books" for the Scribner's Classics series, including Kidnapped, Robin Hood, Westward Ho!, The Mysterious Island, The Boy's King Arthur, The Last of the Mohicans, and twenty other titles.
Wyeth became known for a superb sense of color and his complex compositions. He had a talent for accentuating the palpable, dramatic tension inherent in the stories. Each of his Scribner’s Classics books featured full-color paste down illustrations on the front board and as many as nine or ten additional full-color illustrations throughout the story. The sheer size and scale of his book art, unusual in illustrations of the period, contributed to their heroic quality. “Wyeth's valiant and heroic characters created prototypes of our American heroes, which have lasted to set the standard for movie, television, and computer game heroes.” (National Museum of American Illustration).
Because of his talent, the Scribner's Classics have never waned in popularity and the books he illustrated are coveted by collectors to this day.